Pretargeting methods and compounds

Details Pretargeting methods and compounds Pretargeting methods and compounds

C - Chemistry, Metallurgy

07

K

C07K 5/12 (2006.01) C07D 257/02 (2006.01) C07K 1/107 (2006.01)

Patent

CA 2177136

Methods of producing nitro-benzyl-DOTA via tosylate cyclization, direct peptide cyclization of cyclic tetrapeptide, and N-alkylation of a compound having a trifluoroacetamide group with an iodoacetyl derivative are described.

L'invention concerne des procédés, des composés, des compositions et du matériel permettant la libération préciblée d'agents diagnostiques et thérapeutiques. Elle concerne en particulier des procédés de marquage radiométalliques de la biotine ainsi que les composés associés. Des articles manufacturés utiles dans lesdits procédés de préciblage sont également décrits.

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