Prevascularized devices and related methods

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/38 (2006.01) A61K 9/00 (2006.01) A61K 35/39 (2006.01) A61K 38/28 (2006.01) A61L 27/14 (2006.01) A61L 27/16 (2006.01) A61L 27/54 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2610646

The present invention provides an implantable devices for providing a biologically active agent to a subject in need thereof, the device comprising a microvessel construct in contact with a biocompatible, semi-permeable pouch, the pouch encapsulating a cell or cells capable of producing the biologically active agent. The present invention also provides methods for treating or preventing a disorder in a subject using the implantable device. The present invention also provides specific methods for treating or preventing diabetes in a subject comprising implanting in the subject an immunoisolation device comprising a microvessel construct in contact with a biocompatible, semi- permeable pouch, the pouch encapsulating a cell or cells capable of producing a therapeutically effective amount of insulin. Methods for vascularizing and revascularizing tissue, including engineered tissue, are also provided.

La présente invention concerne des dispositifs implantables permettant d'administrer un agent biologiquement actif à un sujet qui en a besoin. Ce dispositif comprend un structure de mini-vaisseaux en contact avec une poche biocompatible, semi-perméable, dans laquelle sont encapsulées une ou plusieurs cellules capables de produire l'agent biologiquement actif. La présente invention concerne également des méthodes de traitement ou de prévention de troubles chez un sujet au moyen du dispositif implantable, et plus spécifiquement des méthodes de traitement ou de prévention du diabète chez un sujet. Ces méthodes consistent à implanter un dispositif d'immuno-isolation comprenant une structure de mini-vaisseaux en contact avec une poche biocompatible, semi-perméable, dans laquelle sont encapsulées une ou plusieurs cellules capable de produire une dose thérapeutiquement efficace d'insuline. Sont également décrites des méthodes de vascularisation et de revascularisation de tissus.

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