A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/38 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2643711
The invention relates to a tissue transplant construct for reconstructing a human or animal organ, particularly the bladder, ureter, or urethra. Said tissue transplant construct comprises a) a biologically compatible acellular membrane, and b) microvascular endothelial cells which penetrate the membrane, microvascular structures from the microvascular endothelial cells being embodied within the membrane. Also disclosed is a method for producing a tissue transplant construct. Said method encompasses the following steps: a) microvascular endothelial cells are isolated; b) said microvascular endothelial cells are applied to a biologically compatible acellular membrane; c) the microvascular endothelial cells applied to the biologically compatible acellular membrane are cultivated using stromal or epithelia-stromal induction (e.g. by means of a conditioned medium).
L'invention concerne une construction de transplantation tissulaire destinée à la reconstruction d'un organe humain ou animal, comportant (a) une membrane acellulaire biologiquement compatible et (b) des cellules endothéliales microvasculaires traversant la membrane. Des structures microvasculaires composées des cellules endothéliales microvasculaires sont créées dans la membrane.
Ram-Liebig Gouya
Wirth Manfred
Lesperance & Martineau S.e.n.c.
Technische Universitaet Dresden
Urotec Gmbh
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