Preventing allograft rejection with antibodies to adhesion...

Details Preventing allograft rejection with antibodies to adhesion... Preventing allograft rejection with antibodies to adhesion...

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2120500

2120500 9306864 PCTABS00021 Compositions and methods for prolonging the function of a transplanted allograft and preventing transplant rejection are provided. Particularly, tolerance is induced in a recipient mammal to a transplanted organ or tissue by treatment with a composition comprising more than one adhesion molecule inhibitor including antibodies to the adhesion molecule and corresponding ligand, e.g. antibodies to LFA-1 and ICAM-1. Compositions of the invention find additional use in treating inflammatory reactions, as well as allergies and autoimmune diseases.

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