Preventing atrial fibrillation (af) with the use of statin...

A - Human Necessities – 61 – K

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A61K 31/222 (2006.01) A61K 31/351 (2006.01) A61P 9/06 (2006.01)

Patent

CA 2529367

The present invention relates to a novel method to prevent or attenuate atrial fibrillation (AF) promotion resulting from atrial tachycardia. In a study conducted with 39 dogs, the HMG-CoA reductase inhibitor simvastatin was found to significantly attenuate AF promotion. This finding constitutes the basis for an interesting new pharmaceutical approach for preventing the consequences of atrial tachycardia remodeling.

L'invention porte sur une nouvelle méthode de prévention ou atténuation de la promotion de la fibrillation auriculaire, à l'origine de la tachycardie auriculaire. Dans une étude effectuée sur 39 chiens, on a trouvé que la simvastatine, inhibiteur de la HMG-CoA réductase, atténuait significativement la promotion de ladite fibrillation. Cette découverte est la base d'une nouvelle approche pharmaceutique prévenant les conséquences d'un remodelage de la tachycardie auriculaire.

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