A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61P 25/28 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2414772
The present invention relates to prevention and treatment of Alzheimer's disease (AD). More specifically, the invention relates to use of a non-wild type protofibril or compound(s) with protofibril forming activity for active immunisation in the purpose of treating or preventing AD. The invention further relates to a peptide, a.szlig.-Arc, with high protofibril forming activity as well as several applications thereof, such as antibodies against said peptide for passive immunisation against AD.
La présente invention concerne la prévention et le traitement de la maladie d'Alzheimer. De manière spécifique, cette invention a trait à l'utilisation d'une protofibrille de type non sauvage ou d'un/de composé(s) présentant une activité de production de protofibrille, destinée à l'immunisation active, en vue de traiter ou de prévenir la maladie d'Alzheimer. La présente invention concerne également un peptide, .beta.A-Arc, présentant une forte activité de production de protofibrille, ainsi que diverses applications de celui-ci, telles que des anticorps destinés à lutter contre ledit peptide, en vue d'une immunisation passive contre la maladie d'Alzheimer.
Lannfelt Lars
Naslund Jan
Nilsberth Camilla
Westlind-Danielsson Anita
Bioarctic Neuroscience Ab
Bioartic Neuroscience Ab
Cassan Maclean
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