Prevention and treatment of amyloidogenic disease

Details Prevention and treatment of amyloidogenic disease Prevention and treatment of amyloidogenic disease

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2370311

The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of A.beta. in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are useful for prophylactic and therapeutic treatment of Alzheimer's disease. Preferred agents including N- terminal fragments of A.beta. and antibodies binding to the same.

L'invention concerne des compositions et des procédés utiles pour le traitement de maladies amyloïdogènes liées au dépôt amyloïde de A.beta. sur l'encéphale d'un patient. De tels procédés consistent à administrer des agents induisant une réponse immunogène utile contre le dépôt amyloïde. Ces procédés sont utiles à des fins de traitements prophylactiques et thérapeutiques de la maladie d'Alzheimer. L'invention concerne également des agents contenant des fragments de N-terminal de A.beta. et des anticorps se fixant à eux.

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