Prevention and treatment of androgen-deprivation induced...

A - Human Necessities – 61 – K

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A61K 31/138 (2006.01) A61K 45/00 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2468719

This invention provides: 1) a method of treating androgen-deprivation induced osteoporosis and/or bone fracture and/or loss of Bone Mineral Density (BMD) in a male subject suffering from prostate cancer; 2) a method of preventing androgen-deprivation induced osteoporosis and/or bone fractures and/or loss of Bone Mineral Density (BMD) in a male subject suffering from prostate cancer; 3) a method of suppressing or inhibiting androgen-deprivation induced osteoporosis and/or bone fractures and/or loss of BMD in a male subject suffering from prostate cancer; and 4) a method of reducing the risk of developing androgen-deprivation induced osteoporosis and/or bone fractures and/or loss of BMD in a male subject suffering from prostate cancer, by administering to the subject a pharmaceutical composition comprising an anti- estrogen agent and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof as described herein.

La présente invention concerne: 1) une technique de traitement de l'ostéoporose et/ou des fractures osseuses et/ou de la perte de densité minérale osseuse induites par la privation d'androgène chez l'homme souffrant d'un cancer de la prostate, 2) une technique de prévention de l'ostéoporose et/ou des fractures osseuses et/ou de la perte de densité minérale osseuse induites par la privation d'androgène chez l'homme souffrant d'un cancer de la prostate, 3) une technique permettant de supprimer ou d'inhiber l'ostéoporose et/ou des fractures osseuses et/ou la perte de densité minérale osseuse induites par la privation d'androgène chez l'homme souffrant d'un cancer de la prostate et, 4) une technique permettant de réduire le risque de développer une ostéoporose et/ou des fractures osseuses et/ou une perte de densité minérale osseuse induites par la privation d'androgène chez l'homme souffrant d'un cancer de la prostate. Ces techniques consistent à administrer au patient une composition pharmaceutique comprenant un agent anti-oestrogène et/ou un analogue, un dérivé, un isomère, un métabolite ou un sel de celui-ci, ce sel répondant aux normes pharmaceutiques, un produit pharmaceutique, un hydrate, N-oxyde ou une combinaison quelconque de ceux-ci, telle que décrite dans les spécifications.

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