A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7068 (2006.01) A61K 31/505 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) A61K 31/7072 (2006.01) A61K 31/7076 (2006.01) A61K 31/708 (2006.01) C07D 239/47 (2006.01) C07D 239/54 (2006.01) C07D 473/28 (2006.01) C07D 473/34 (2006.01) C07H 19/067 (2006.01) C07H 19/073 (2006.01) C07H 19/167 (2006.01) C07H 19/173 (2006.01)
Patent
CA 2644297
Nucleoside chemical compounds, which interact with specific structures of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) are disclosed. The compounds interfere with the activities of telomerase and reverse transcriptase, and are useful as antivirals, antibacterials and anticancer agents. Methods of treating or preventing cancers in patients involving administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptases (RTs) expressed in cells of the patients are also disclosed. Method of using nucleoside analogs and other inhibitors of RTs in conjunction with DNA damaging agents such as genotoxic agents or radiation or photodynamic therapy or combinations these for the treatment of various cancers are also disclosed.
L'invention concerne des composés chimiques nucléosidiques qui interagissent avec des structures spécifiques de l'acide désoxyribonucléique (ADN) ou de l'acide ribonucléique (ARN). Lesdits composés interfèrent avec les activités de la télomérase et de la transcriptase inverse et sont utiles en tant qu'agents antiviraux, antibactériens et anticancéreux. L'invention concerne également des procédés de traitement ou de prévention des cancers impliquant d'administrer une quantité efficace sur le plan thérapeutique d'une composition comprenant un inhibiteur ou un antagoniste des transcriptases inverses (RT) exprimées dans les cellules des patients. Est également décrit un procédé d'utilisation d'analogues nucléosidiques et d'autres inhibiteurs des RT conjointement à des agents endommageant l'ADN (agents génotoxiques ou radiations ou thérapie photodynamique ou l'une de leurs combinaisons, par exemple) dans le but de traiter divers cancers.
Alt Solutions Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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