A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 33/00 (2006.01) A61P 13/02 (2006.01) A61P 13/12 (2006.01)
Patent
CA 2687426
The present invention provides a method of attenuating or preventing acute kidney injury occurring in a subject following cardiac surgery involving cardio-pulmonary bypass. The method comprises administration of at least one agent which cause alkalinization of urine to the subject at a level effective to cause alkalinization of the subject's urine. Preferably the agent which cause alkalinization of urine is selected from the group consisting of sodium bicarbonate, lactate, acetate, citrate, tromethamine and combinations thereof and is most preferably sodium bicarbonate.
L'invention porte sur une méthode d'atténuation ou de prévention de l'insuffisance rénale aiguë survenant chez un patient après une chirurgie cardiaque comportant une dérivation cardio-pulmonaire. La méthode comprend l'administration d'au moins un agent efficace d'alcalinisation de l'urine du patient. L'agent étant de préférence choisi parmi le bicarbonate, le lactate, l'acétate et le citrate, de sodium, la trométhamine ou leurs combinaisons, le bicarbonate de sodium étant privilégié.
Bellomo Rinaldo
Haase Michael
Austin Health
Osler Hoskin & Harcourt Llp
LandOfFree
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