C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 16/38 (2006.01) C07K 16/44 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2354863
Methods for the prevention of adhesion formation involve the administration of therapeutic formulations to a patient which include antibodies to TIMP-1 or TIMP-1 antisense oligonucleotides. The formulations can also include suitable carriers, such as a hyaluronic acid matrix, for optimal administration. The treatment procedure can be initiated and monitored by a diagnostic procedure which involves the detection of elevated levels of TIMP-1 in a patient.
L'invention concerne des procédés de prévention de l'adhérence, qui consiste à administrer des formulations thérapeutiques à un patient, notamment des anticorps aux oligonucléotides TIMP-1 ou oligonucléotides antisens TIMP-1. Les formulations peuvent également comprendre des porteurs appropriés, tels qu'une matrice d'acide hyaluronique pour une administration optimale. On peut lancer la procédure de soins et la surveiller par une procédure diagnostique qui implique la détection de niveaux élevés de TIMP-1 chez le patient.
Burns James
Chegini Nasser
Diamond Michael
Holmdahl Lena
Burns James
Chegini Nasser
Diamond Michael
Genzyme Corporation
Holmdahl Lena
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