A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 31/00 (2006.01) A61K 38/05 (2006.01)
Patent
CA 2419132
Compositions and methods for inhibiting neurotoxic ubiquitin-proteasome proteolysis, and treatment of neurodegenerative disorders. In particular, a method of suppressing the neurotoxic effect of .beta.-amyloid peptide, by administering an inhibitor to block .beta.-amyloid peptide-mediated ubiquitin- proteasome proteolysis. Preferred inhibitors are inhibitors of ubiquitination, such as leucine-alanine dipeptide, and inhibitors of post-ubiquitination proteasome activity, such as lactacystin.
Cette invention concerne des compositions et des méthodes permettant d'inhiber la protéolyse neurotoxique de l'ubiquitine-protéasome, ainsi que le traitement des maladies neurodégénératives. L'invention concerne en particulier une méthode propre à supprimer l'effet neurotoxique du peptide .beta.-amyloïde par administration d'un inhibiteur qui bloque la protéolyse de l'ubiquitine-protéasome induite par un peptide .beta.-amyloïde. Parmi les inhibiteurs préférés figurent des inhibiteurs d'ubiquitination, tels qu'un dipeptide de leucine-alanine, et des inhibiteurs de l'activité protéasome tel que la lactacystine.
Alkon Daniel L.
Favit Antonella
Grimaldi Maurizio
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Government Of The United States Of America
LandOfFree
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