Prevention of colorectal cancer

Details Prevention of colorectal cancer Prevention of colorectal cancer

A - Human Necessities

61

K

A61K 33/06 (2006.01) A61K 31/593 (2006.01) A61K 31/616 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2385755

The present invention relates to a method for prevention of colorectal cancer or the initiation and/or progression of colorectal cancer in a human comprising administration to the human a combination dosage of a cyclooxygenase (COX) inhibitor, a vitamin D3 including analogues and metabolites thereof and calcium. In a further embodiment the invention relates to the use of the combination dosage for the preparation of a medicament and to such pharmaceutical preparations. In a further aspect the invention relates method for reducing the effective dosage of ASA in a chemoprofylactive treatment of colorectal cancer in a human by co-administration with a non toxic dosage of a vitamin D3 including analogues and metabolites thereof and Ca in the form of a combination dosage.

L'invention concerne une méthode de prévention du cancer colorectal ou de l'apparition et/ou de la progression du cancer colorectal chez l'homme. Cette méthode consiste à administrer au patient une dose d'une combinaison comprenant un inhibiteur de cyclooxygénase (COX), de la vitamine D3 y compris des analogues ou des métabolites celle-ci, et du calcium. Dans un second aspect, l'invention concerne l'utilisation de cette combinaison dans la préparation d'un médicament et de préparations pharmaceutiques similaires. Dans un troisième aspect l'invention concerne une méthode permettant de réduire le dosage efficace d'AAS dans un traitement chimiopréventif du cancer colorectal chez l'homme, grâce à l'administration simultanée d'une dose non toxique de vitamine D3 ou d'analogues ou de métabolites de celle-ci, et de Ca, présentés sous forme d'une combinaison.

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