C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/00 (2006.01) C07K 14/00 (2006.01)
Patent
CA 2691692
The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.
La présente invention a pour objet des procédés et des moyens de prévention de la réduction des liaisons disulfure au cours de la production recombinante de polypeptides contenant des liaisons disulfure. En particulier, l'invention concerne la prévention de la réduction des liaisons disulfure au cours de la récolte de polypeptides contenant des liaisons disulfure, y compris des anticorps, à partir de cultures de cellules hôtes recombinantes.
Hewitt Daniel P.
Kao Yung-Hsiang
Laird Michael W.
Schmidt Melody Trexler
Wong Rita L.
Genentech Inc.
Smart & Biggar
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