A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 33/00 (2006.01) A61B 1/00 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 9/08 (2006.01) A61K 9/20 (2006.01) A61K 31/04 (2006.01) A61K 31/095 (2006.01) A61K 31/167 (2006.01) A61K 31/724 (2006.01) A61K 33/04 (2006.01) A61K 47/40 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2467245
NO, NO donor or prodrug that causes formation of nitrosothiol in tissue optionally in combination with lidocaine is topically applied to pedicle of a pedicle flap or other source of blood supply to prevent necrosis in pedicle flap or in any microvascular surgery. Composition containing drug is formulated with nitrosylated polythiolated cyclodextrin to improve drug delivery.
L'invention concerne l'application topique de monoxyde d'azote (NO), d'un donneur de NO, ou d'un promédicament entraînant la formation de nitrosothiole dans les tissus, éventuellement associé à de la lidocaïne, sur le pédicule d'un lambeau pédiculé ou d'un autre système d'irrigation sanguine, pour empêcher la nécrose d'un lambeau pédiculé, ou dans une autre application de chirurgie microvasculaire. Pour améliorer l'administration de médicaments, la composition qui contient ce médicament est préparée avec de la cyclodextrine polythiolée et nitrosylée.
Stamler Jonathan S.
Toone Eric J.
Zenn Michael R.
Duke University
Ridout & Maybee Llp
LandOfFree
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