Prevention of graft-versus-host disease with t-cells...

Details Prevention of graft-versus-host disease with t-cells... Prevention of graft-versus-host disease with t-cells...

A - Human Necessities

61

K

A61K 35/14 (2006.01) A61K 31/52 (2006.01) A61K 39/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2255941

A method of preventing graft-versus-host disease in a patient being treated for relapsed or persistent leukemia. The method comprises administering to a host allogeneic T-cells genetically engineered to include a polynucleotide encoding a negative selective marker. Prior to the occurrence of graft-versus- host disease, an interaction or chemotherapeutic agent is administered to the host, which kills the genetically engineered T-cells, thereby preventing the occurrence of graft-versus-host disease. Such method also may be employed in connection with the treatment of any disease or disorder wherein the treatment includes bone marrow ablation followed by the administration of a T-cell depleted bone marrow transplant.

Cette invention concerne un procédé de prévention de la réaction du greffon contre l'hôte chez un patient traité pour leucémie persistante ou récurrente. Ledit procédé consiste à administrer à un hôte des lymphocytes thymo-dépendants produits par génie génétique de façon à incorporer un polynucléotide codant un marqueur de sélection négative. Avant l'apparition de la réaction du greffon contre l'hôte, on administre à l'hôte un agent d'interaction ou un agent chimiothérapeutique qui détruit les lymphocytes thymo-dépendants produits par génie génétique et empêche l'apparition de ladite réaction. On peut mettre en oeuvre ce procédé parallèlement au traitement de toute maladie ou trouble impliquant une ablation de moelle osseuse suivie d'une greffe de moelle osseuse appauvrie en lymphocytes thymo-dépendants.

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