A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/22 (2006.01) A61K 31/366 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 38/17 (2006.01) A61K 45/06 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2522089
The invention generally relates to a method of preventing or slowing down a retroviral infection through the use of agents which prevent the aggregation of retroviral receptors that are associated with the raft domains of the cell membranes. More specifically, the invention relates to the prevention or treatment of a HIV-1 infection through the use of agents which inhibit the activation of Rho-A, by acting on GTPase activity or on protein isoprenylation. The invention also relates to a method of preventing or slowing down a HIV-1 infection by moving the receptors for cytokines of the raft domains of the cell membranes.
L'invention concerne, de manière générale, la prévention ou l'inhibition d'une infection rétrovirale par l'utilisation d'agents empêchant l'agrégation de récepteurs rétroviraux associés aux domaines avec réservoirs des membranes cellulaires. Cette invention concerne, plus particulièrement, la prévention ou le traitement d'une infection par VIH-1 en utilisant des agents inhibant l'activation de Rho-A, agissant sur l'activité de la GTPase ou sur l'isoprénilation de protéines. Cette invention concerne également la prévention ou l'inhibition d'une infection par le VIH-1 par déplacement de récepteurs de cytokines des domaines à réservoirs des membranes cellulaires.
Alonso Carlos Martinez
Del Real Gustavo
Manes Santos
Mellado Mario
Rodriguez Frade Jose Miguel
Alonso Carlos Martinez
Consejo Superior de Investigaciones Cientificas
Del Real Gustavo
Manes Santos
Mellado Mario
LandOfFree
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