A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/74 (2006.01) A01N 25/34 (2006.01) A61F 2/00 (2006.01) A61K 38/36 (2006.01) A61K 38/44 (2006.01) A61K 38/48 (2006.01) A61L 24/10 (2006.01) A61L 31/04 (2006.01)
Patent
CA 2373704
A method and a composition for preventing or reducing the incidence of post surgical adhesion formation is disclosed. The method involves application of fibrin monomer composition under polymerizing conditions to the surgical wound site. The fibrin monomer composition free of exogenous thrombin, free from proteins, enzymes or polymers foreign to the patient polymerize at the surgical wound site to form the fibrin polymer that provides hemostasis and promotes wound healing while functioning as a barrier/sealant. Autologous plasma proteins derived from the patient's blood may be added to the sealant composition before or during application to the surgical wound site.
L'invention concerne un procédé et une composition de prévention ou de réduction de l'incidence de la formation d'adhérences post-chirurgicales. Le procédé consiste à appliquer une composition de monomère de fibrine dans des conditions de polymérisation sur le site de la blessure chirurgicale. La composition de monomère de fibrine exempte de thrombine exogène, exempte de protéines, d'enzymes ou de polymères étrangers au patient se polymérise au site de la blessure chirurgicale de manière à former un polymère de fibrine fournissant une hémostase et provoquant la subérification de la blessure tout en servant de barrière/scellement. Des protéines de plasma autologues issues du sang du patient peuvent être ajoutées à la composition de scellement avant ou pendant son application sur le site de la blessure chirurgicale.
Amery Michael J.
Burnett Stuart
Cederholm-Williams Stewart A.
Edwardson Peter A. D.
Griffin H. Eugene
Bristol-Myers Squibb Company
Osler Hoskin & Harcourt Llp
Vivolution A/s
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