Prevention of prosthesis calcification

Details Prevention of prosthesis calcification Prevention of prosthesis calcification

A - Human Necessities

61

L

167/326

A61L 27/00 (2006.01) A61L 27/36 (2006.01) A61L 27/50 (2006.01)

Patent

CA 1307743

PREVENTION OF PROSTHESIS CALCIFICATION Abstract of Disclosure A method for retarding or preventing the calcification of a prosthesis implanted in a mammal by covalently coupling to the prosthesis before implantation an effective amount of an anticalcification agent in the form of an aliphatic carboxylic acid, or a derivative thereof, which contains from about 8 to about 30 carbon atoms and which may be straight-chain or branched-chain and saturated or unsaturated. Such acid is substituted by at least one amino, mercapto, carboxyl or hydroxyl group by which the covalent coupling takes place. For a natural tissue prosthesis, such coupling may be to an aldehyde group of gluteraldehyde in which the tissue is pre-soaked.

589742

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