A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 31/04 (2006.01) C07K 16/12 (2006.01) C07K 14/31 (2006.01)
Patent
CA 2683778
The present application discloses antibodies directed to protein SE2232 (SesC) of Staphylococcus epidermis, and homologus proteins which are useful in preventing biofilm formation by said micro-organism. The antibodies can be used to coat medical devices which are inserted or implanted into the mammalian, preferably human body. Further these antibodies or vaccines comprising said proteins can be used to vaccinate subjects to prevent or treat natural occurring biofilm formation during infection. Also covered are medical devices coated with the antibody.
La présente invention concerne des anticorps visant la protéine SE2232 (SesC) du staphylocoque épidermique, ainsi que des protéines homologues utilisables dans le cadre de la prévention de la formation d'un biofilm par lesdits microorganismes. Ces anticorps peuvent être utilisés pour revêtir la surface des instruments médicaux à implanter ou introduire dans un organisme mammifère et, de préférence, humain. En outre, ces anticorps ou vaccins comprenant lesdites protéines peuvent être utilisés pour la vaccination de sujets afin de prévenir ou de traiter la formation d'un biofilm naturel lors d'une infection. La présente invention concerne également des dispositifs médicaux revêtus de ces anticorps.
Hermans Peter Wilhelmus Maria
Van Eldere Johan
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Katholieke Universiteit Leuven
Stichting Katholieke Universiteit More Particulary The Radboud Universi Ty Nijmegen Medical Centre
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