Prevention of thrombotic disorders with active vitamin d...

A - Human Necessities – 61 – K

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A61K 31/59 (2006.01) C07C 401/00 (2006.01)

Patent

CA 2593982

The present invention relates to a method for preventing, treating, or ameliorating thrombotic disorders in an animal comprising administering to the animal an active vitamin D compound or a mimic thereof. According to the invention, the active vitamin D compound or the mimic thereof may be administered by HDPA so that high doses of the active vitamin D compound or the mimic thereof can be administered to an animal without inducing severe symptomatic hypercalcemia. The invention also relates a method for preventing, treating, or ameliorating thrombotic disorders in an animal comprising administering to the animal an active vitamin D compound or a mimic thereof in combination with one or more other therapeutic agents.

La présente invention concerne un procédé pour prévenir, traiter ou améliorer des troubles thrombotiques chez un animal. Ce procédé consiste à administrer à l'animal un composé de vitamine D active ou un mimétique de celui-ci. Selon cette invention, le composé de vitamine D active ou le mimétique de celui-ci peut être administré par thérapie pulsée à forte dose (HDPA), de manière à pouvoir être administré à fortes doses à un animal, sans induire d'hypercalcémie symptomatique grave. Cette invention concerne également un procédé pour prévenir, traiter ou améliorer des troubles thrombotiques chez un animal. Ce procédé consiste à administrer à l'animal un composé de vitamine D active ou un mimétique de celui-ci, combiné à un ou plusieurs autres agents thérapeutiques.

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