Prevention of type 1 diabetes and other non-polio...

A - Human Necessities – 61 – K

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A61K 39/125 (2006.01) A61K 39/13 (2006.01)

Patent

CA 2376923

Live virus vaccines comprise attenuated viruses, while other vaccines comprise killed viruses or parts thereof. It has now been found that the immune response induced by oral poliovirus vaccine (OPV), which is a live vaccine, is cross-reactive with non-polio enteroviruses. OPV is therefore useful in the prevention of non-polio enterovirus diseases, especially Type 1 diabetes mellitus (IDDM). OPV is also useful in combination with killed/subunit non- polio enterovirus vaccines, whereby it prevents harmful side-effects of the killed/subunit vaccine by shifting the immune response from a harmful Th2- type response to a Th1 type response.

Les vaccins à virus actif comprennent des virus atténués alors que d'autres virus renferment des virus tués complets ou partiels. On a découvert que la réponse immunitaire déclenchée par le vaccin contre le poliovirus à administration orale (OPV), vaccin à virus actif, présente une activité croisée avec les maladies entérovirales autres que la poliomyélite. L'OPV convient donc pour la prévention de maladies à entérovirus autres que la poliomyélite, singulièrement le diabète insulino-dépendant sucré. L'OPV est également utile en tant que combinaison avec des vaccins entéroviraux tués/sous-unitaires non polio, dans la mesure où il permet d'éviter les effets secondaires dommageables du vaccin tué/sous-unitaire en remplaçant une réponse immunitaire de type Th2, dangereuse, en une réponse de type Th1.

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