Prevention of uveitis

Details Prevention of uveitis Prevention of uveitis

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61K 39/09 (2006.01) A61K 39/106 (2006.01) A61K 47/48 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07K 14/28 (2006.01) C07K 14/315 (2006.01) C07K 14/47 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2454705

Disclosed herein is a conjugate with recombinant cholera toxin B sub-unit (rCTB) of a peptide or polypeptide consisting of or containing a sequence corresponding to amino acid residues 336-351 of the human heat shock protein HSP 60, or the corresponding residues of the microbial 65kD heat shock protein, or one which difers from either of these by up to and including 4 amino acid alterations (sub-situation and/or deletion and/or insertion) and having similar tolerising properties for Behcet's disease, or related types of uveitis, by oral, nasal, transmucosal or parenteral administration, or one which is extended from any one of the above-mentioned residues at the N-terminus or C-terminus or both with one or more non-wild-type amino acid sequences. Also disclosed are pharmaceutical compositions embodying the conjugate and methods of using the conjugate.

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