Prevention, treatment, and amelioration of radiation induced...

A - Human Necessities – 61 – K

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A61K 31/16 (2006.01)

Patent

CA 2556373

The present invention provides a new method of ameliorating and/or treating enteritis induced by radiation therapy, alone or in combination with other therapies, for the treatment of, for example, gastrointestinal malignancies, including colorectal, appendiceal, anal, or small bowel cancers; urogenital malignancies, including prostate, ladder, testicular, or penile cancers; gynecologic malignancies, including cervical, endometrial, ovarian, vaginal, or vulvar cancers; or osteogenic and other sarcomatous malignancies in which pelvic structures are involved, comprising the administration of a therapeutically effective amount of balsalazide to a patient in need thereof.

L'invention concerne une nouvelle méthode d'atténuation et/ou de traitement de l'entérite induite par une radiothérapie, seule ou combinée à d'autres thérapies, pour le traitement, par exemple, de tumeurs gastro-intestinales malignes, dont les tumeurs colorectales, appendiculaires, anales, ou les cancers du grêle ; les tumeurs urogénitales, dont les cancers de la prostate, de la vessie, du testicule ou du pénis ; des tumeurs gynécologiques, dont les cancers du col de l'utérus, de l'ovaire, du vagin ou de la vulve ; ou d'autres tumeurs malignes ostéogéniques et sarcomateuses dans lesquelles les structures pelviennes sont impliquées. Ladite méthode consiste à administrer une dose efficace au plan thérapeutique de balsalazide à un patient en ayant besoin.

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