C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2487528
The invention provides compositions and methods for prevention and treatment of diseases associated with .beta.-amyloid formation and/or aggregation. Such methods encompass the induction of an immune response against N-terminal truncated and/or post-translationally modified A.beta. peptides. These peptides are further used in compositions and methods for the diagnosis of diseases associated with .beta.-amyloid formation and/or aggregation.
L'invention concerne des compositions et des méthodes de prévention et de traitement de maladies associées à la formation et/ou à l'agrégation de la .beta.-amyloïde. Ces méthodes englobent l'induction d'une réponse immune contre des peptides AB à troncature N-terminale et/ou à modification post-translationnelle. Ces peptides sont aussi utilisés dans des compositions et des méthodes de diagnostic des maladies associées à la formation et/ou à l'agrégation de la .beta.-amyloïde.
Delacourte Andre
Sergeant Nicolas
Innogenetics N.v.
Institut National de La Sante Et de La Recherche Medicale (inser
Smart & Biggar
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