Preventive and/or therapeutic agent for neutrophilic...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2557276

A preventive and/or therapeutic agent for neutrophilic inflammation diseases which contains as an active ingredient either a bicyclic heterocyclic compound represented by the formula (I) [wherein R1 represents hydrogen, (un)substituted lower alkyl, etc.; A1-A2-A3-A4 represents N=CR3-CR4=CR5 (wherein R3, R4, and R5 are the same or different and each represents hydrogen, (un)substituted lower alkyl, etc.), etc.; Q represents (un)substituted phenylene, etc.; and T represents (un)substituted lower alkyl, (un)substituted aroyl, etc.] or a pharmacologically acceptable salt of the compound.

Agent préventif et/ou thérapeutique pour des maladies inflammatoire neutrophile lequel contient comme ingrédient actif soit un composé hétérocyclique bicyclique représenté par la formule (I) : (I) [dans laquelle R?1¿ représente un hydrogène, un alkyle inférieur substitué ou non, etc. ; A?1¿-A?2¿-A?3¿-A?4¿ représente N=CR?3¿-CR?4¿=CR?5¿ (où R?3¿, R?4¿ et R?5¿ sont identiques ou différents et représentent chacun un hydrogène, un alkyle inférieur substitué ou non, etc.), etc. ; Q représente un phénylène substitué ou non, etc. ; et T représente un alkyle inférieur substitué ou non, un aroyle substitué ou non, etc.] soit un sel acceptable du point de vue pharmacologique du composé.

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