Preventive cancer vaccine based on brother of regulator of...

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A61K 39/00 (2006.01) C12N 5/0784 (2010.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2537161

Polynucleotides encoding a nonfunctional mutant form of the Brother of Regulator of Imprinted Sites (BORIS) molecule, nonfunctional mutated BORIS protein, polypeptide or peptide and modified protein forms of BORIS are described. These molecules are used as a therapeutic vaccine against cancer.

L'invention concerne des polynucléotides codant une forme mutante non fonctionnelle de la molécule BORIS (frère du régulateur de sites marqués), une protéine BORIS mutée non fonctionnelle, un polypeptide ou un peptide et des formes protéiques modifiées de la molécule BORIS. Ces molécules sont utilisées en tant que vaccin thérapeutique contre le cancer.

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