Preventive or remedy for bowel disease

Details Preventive or remedy for bowel disease Preventive or remedy for bowel disease

A - Human Necessities

61

K

A61K 31/4439 (2006.01) A61K 31/415 (2006.01) A61K 45/00 (2006.01) A61P 1/04 (2006.01) A61P 1/12 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2606239

It is intended to provide a preventive or a remedy for inflammatory colitis, irritable bowel syndrome and various diarrhea caused by other factors. It was found for the first time that CRAC/SOC channel plays a physiologically important role in water secretion or absorption in gastrointestinal epithelial cells and a CRAC/SOC channel inhibitor is useful for preventing and treating diarrhea caused by various factors, and a preventive and a remedy for diarrhea comprising a compound inhibiting the calcium release activated calcium channel as an active ingredient, particularly a remedy for diarrheal symptoms associated with inflammatory bowel diseases and a remedy for irritable bowel syndrome are provided.

L'invention concerne un agent prophylactique ou un agent thérapeutique contre la colite inflammatoire, le syndrome du côlon irritable et diverses diarrhées causées par d'autres facteurs. On a découvert pour la première fois que le canal CRAC/SOC joue un rôle physiologiquement important dans la sécrétion ou l'absorption d'eau dans les cellules épithéliales gastro-intestinales et qu'un inhibiteur du canal CRAC/SOC est utile pour prévenir et traiter la diarrhée causée par divers facteurs. L'invention concerne un agent prophylactique et un agent thérapeutique contre la diarrhée renfermant un composé inhibant le canal calcique activé par libération de calcium comme ingrédient actif, et notamment un agent thérapeutique contre les symptômes diarrhéiques associés aux maladies intestinales inflammatoires et un agent thérapeutique contre le syndrome du côlon irritable.

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