Preventive or therapeutic agent for cardiac dysfunction or...

Details Preventive or therapeutic agent for cardiac dysfunction or... Preventive or therapeutic agent for cardiac dysfunction or...

A - Human Necessities

61

K

A61K 31/4188 (2006.01) A61P 9/00 (2006.01) C07D 491/107 (2006.01)

Patent

CA 2633940

An object of the present invention is to provide a preventive or therapeutic agent for cardiac dysfunction or myocardial injury caused by ischemia or ischemia reperfusion, which exhibits effectiveness by a different mechanism from that of the existing therapeutics, and can be taken for a long period. The present invention is a preventive or therapeutic agent for cardiac dysfunction or myocardial injury caused by ischemia or ischemia reperfusion, containing 6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-car boxamide, in particular, fidarestat as an active ingredient. Examples of the cardiac dysfunction or myocardial injury caused by ischemia or ischemia reperfusion include reperfusion arrhythmia, cardiac event, cardiac death and the like.

L'invention entend proposer un agent préventif ou thérapeutique pour dysfonction cardiaque ou dommage myocardique provoqué par ischémie ou reperfusion d'ischémie, ayant l'efficacité d'un mécanisme d'action différent d'un agent thérapeutique conventionnel et que l'on peut prendre sur une période prolongée. L'invention concerne donc un agent préventif ou thérapeutique pour dysfonction cardiaque ou dommage myocardique provoqué par ischémie ou reperfusion d'ischémie comprenant de la 6-fluoro-2',5'-dioxospiro[chroman-4,4'- imidazolidine]-2-carboxamide, en particulier du fidarestat, comme ingrédient actif. Des exemples de dysfonction cardiaque ou de dommage myocardique provoqué par ischémie ou reperfusion d'ischémie englobent l'arythmie de reperfusion d'ischémie, l'attaque cardiaque, l'arrêt cardiaque et autre.

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