Preventive or therapeutic agent for diseases caused by...

A - Human Necessities – 61 – K

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A61K 31/426 (2006.01) A61K 33/42 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2694638

An object of the present invention is to provide a preventive drug and a therapeutic drug for diseases caused by abnormal bone metabolism, especially osteoporosis, which is more effective than conventional drugs. Combined use of N-hydroxy-4-{5-[4-(5- isopropyl-2-methyl-1, 3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine, or a salt thereof; and at least one compound selected from the group consisting of etidronic acid, clodronic acid, pamidronic acid, tiludronic acid, risedronic acid, minodronic acid, ibandronic acid, zoledronic acid, and salts thereof can exert higher bone resorption inhibitory effect and provide a preventive effect and a therapeutic effect for diseases caused by abnormal bone metabolism, especially osteoporosis as compared with administration of the respective agents respectively.

L'invention vise à proposer un agent préventif ou un agent thérapeutique pour une maladie provoquée par un métabolisme osseux anormal, en particulier pour l'ostéoporose, qui est plus efficace que jamais. Par une application combinée de N-hydroxy-4-{5-[4-(5-isopropyl-2-méthyl-1,3-thiazol-4-yl)-phénoxy]pentoxy}-benzamidine ou d'un sel de celle-ci et d'un ou plusieurs composés choisis dans le groupe constitué par l'acide étidronique, l'acide clodronique, l'acide pamidronique, l'acide tiludronique, l'acide risédronique, l'acide minodronique, l'acide ibandronique, l'acide zolédronique et des sels de ceux-ci, une action inhibitrice de la résorption osseuse supérieure par comparaison avec l'administration d'un seul composé est présentée, et d'excellents effet préventif et effet thérapeutique pour une maladie provoquée par un métabolisme osseux anormal, en particulier pour l'ostéoporose, peuvent être obtenus.

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