A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61P 1/04 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2709119
The present invention relates to a pharmaceutical composition for preventing or treating inflammatory bowel diseases, which comprises 7,8-d imethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzo - azepine, a prodrug thereof, preferably 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5 H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazepine as a prodrug, or a pharmaceutically acceptable salt thereof. The pharmaceutical composition according to the present invention is effective in the prophylaxis and therapy of the inflammatory bowel diseases and has few side effects. Particularly, the pharmaceutical composition according to the present invention may exhibit strong prophylactic and therapeutic effects even on severe cases having resistance to the conventional therapeutics.
L'invention a pour objet une composition pharmaceutique destinée à prévenir ou à traiter une affection abdominale inflammatoire comprenant de la 7,8-diméthoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzoazépine, un promédicament de cette dernière, de préférence la 2-(1-isopropoxycarbonyloxy-2-méthylpropyl)-7,8-diméthoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazépine comme promédicament, ou un sel pharmacologiquement acceptable de celle-ci. La composition pharmaceutique selon l'invention est efficace pour la prévention et le traitement d'une affection abdominale inflammatoire et présente peu d'effets secondaires. En particulier, la composition pharmaceutique selon l'invention peut présenter un effet préventif et un effet thérapeutique puissants également dans un cas grave présentant une résistance aux agents thérapeutiques existants.
Hoshina Yukari
Kawano Ken-Ichi
Ninomiya Tomohisa
Shishikura Takashi
Takahata Sho
Fetherstonhaugh & Co.
Meiji Seika Kaisha Ltd.
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