Preventive or therapeutic agent for pruritus

A - Human Necessities – 61 – K

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Details

A61K 31/38 (2006.01) A61P 17/04 (2006.01)

Patent

CA 2466790

A pruritus preventive or remedy which contains as an active ingredient either a tricyclic compound represented by the following formula (I): (I) [wherein R1 is hydrogen, (un)substituted lower alkyl, (un)substituted lower alkoxy, or halogeno; X1-X2-X3 is CR5=CR6-CR7=CR8, N(O)m=CR6-CR7=CR8, CR5=CR6-N(O)m=CR8, CR5=CR6-CR7=N(O)m, CR5=CR6-O, CR5=CR6-S, O-CR7=CR8, S-CR7=CR8, or O-CR7=N; and Y is -CH2S-, -CH2SO-, -CH2SO2-, -CH2O-, -CH=CH-, -(CH2)p-, -SCH2-, -SOCH2-, - SO2CH2-, or -OCH2-] or a pharmaceutically acceptable salt of the compound. This application belongs to the medicinal field.

L'invention concerne un agent préventif ou un remède destiné au prurit et renfermant, comme principe actif, soit un composé tricyclique représenté par la formule suivante (I), dans laquelle R1 désigne un hydrogène, un alkyle inférieur (non) substitué, un alcoxy inférieur (non) substitué ou un halogéno; X1-X2-X3 désigne CR5=CR6-CR7=CR8, N(O)m=CR6-CR7=CR8, CR5=CR6-N(O)m=CR8, CR5=CR6-CR7=N(0)m, CR5=CR6-O, CR5=CR6-S, O-CR7=CR8, S-CR7=CR8 ou O-CR7=N et Y représente CH2S-, -CH2SO-, -CH2SO2-, -CH2O-, -CH=CH-, -(CH2)p-, -SCH2-, -SOCH2, -SO2CH2 ou OCH2-, soit un sel acceptable sur le plan pharmaceutique du composé. Cette invention est liée au domaine médicinal.

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