A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/00 (2006.01) A61P 13/02 (2006.01) A61P 13/10 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2531019
It is intended to provide a preventive/remedy for urinary disturbance containing a compound, which shows an acetylcholine esterase inhibitory activity but substantially has no butyrylcholine esterase inhibitory activity, showing no side effect and being safe and efficacious without inhibiting the urine collection function; a preventive/remedy for dry mouth induced by the administration of a remedy for urinary disturbance and a preventive/remedy for hyperactive bladder not accompanied by dry mouth; and a method of screening a substance preventing/treating urinary disturbance without inhibiting the urine collection function characterized by comprising measuring and comparing the acetylcholine esterase inhibitory activity and the butyrylcholine esterase inhibitory activity of a test compound.
L'invention concerne un préventif/médicament permettant de prévenir/traiter une perturbation urinaire, qui contient un composé présentant une activité inhibitrice de l'acétylcholine estérase mais ne présentant sensiblement pas d'activité inhibitrice de la butyrylcholine estérase, sans effets secondaires, et sûr et efficace sans inhiber la fonction de collecte urinaire. L'administration d'un médicament pour perturbation urinaire et d'un préventif/médicament pour hyperactivité de la vessie n'est pas accompagnée d'un effet de bouche sèche. L'invention concerne également une méthode d'analyse d'une substance permettant de prévenir/traiter une perturbation urinaire sans inhiber la fonction de collecte urinaire caractérisée en ce qu'elle consiste à mesurer et à comparer l'activité inhibitrice de l'acétylcholine estérase et d'activité inhibitrice de la butyrylcholine estérase d'un composé d'essai.
Doi Takayuki
Nagabukuro Hiroshi
Fetherstonhaugh & Co.
Takeda Pharmaceutical Company Limited
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