Preventive/therapeutic agent for cancer

A - Human Necessities – 61 – K

Patent

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Details

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2599875

It is intended to identify a novel preventive/therapeutic target molecule of cancer and to provide a preventive/therapeutic agent for cancer that targets the molecule, in other words, a cancer cell apoptosis promoter and/or cancer cell growth inhibitor and a preventive/therapeutic agent for cancer containing an antibody against a protein having an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8 or SEQ ID NO: 10, an antisense polynucleotide of the protein (preferably an siRNA against mRNA of the protein), or a substance that regulates the expression and/or activity of the protein. Further, it is intended to provide a method for screening a cell apoptosis promoting substance and/or cell growth inhibiting substance or a preventive/therapeutic substance for cancer utilizing the protein (preferably a cell producing the protein) and an antibody against the protein, or a polynucleotide encoding the protein.

L~invention permet d'identifier une nouvelle molécule cible préventive/thérapeutique pour le cancer et d'obtenir un agent préventif/thérapeutique pour le cancer qui cible la molécule, en d~autres termes, un promoteur d~apoptose de cellule cancéreuse et/ou un inhibiteur de croissance de cellule cancéreuse et un agent préventif/thérapeutique pour le cancer contenant un anticorps contre une protéine ayant une séquence d~acide aminé identique ou sensiblement identique à une séquence d~acide aminé représentée par SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8 ou SEQ ID NO: 10, un polynucléotide antisens de la protéine (de préférence un ARNsi contre la ARNm de la protéine), ou une substance qui régule l~expression et/ou l~activité de la protéine. En outre, elle porte sur un procédé de criblage d~une substance de promotion d~apoptose cellulaire et/ou une substance inhibitrice de croissance cellulaire ou une substance préventive/thérapeutique pour le cancer utilisant la protéine (de préférence une cellule produisant la protéine) et un anticorps contre la protéine, ou bien un polynucléotide codant pour la protéine.

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