Preventives or remedies for arrhythmia

A - Human Necessities – 61 – K

Patent

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A61K 31/427 (2006.01) A61K 31/422 (2006.01) A61P 9/06 (2006.01) A61P 43/00 (2006.01) C07D 213/61 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2388479

Preventives or remedies for arrhythmia which contain as the active ingredients cPLA2 inhibitors such as compounds represented by general formula (I), wherein R1 represents optionally substituted aralkyl, etc.; Z represents -S-, etc.; X1 represents -(CH2)s-N(R18)-CO- (wherein R18 represents hydrogen, etc.; and s is an integer of 0 to 3), etc.; X2 represents optionally substituted arylene, etc.; X3 represents a single bond, etc.; A, B and E independently represent each oxygen or sulfur; D represents hydrogen, etc.; Y1 represents -(CH2)mCO- (wherein m is an integer of 0 to 3), etc.; and Y2 represents optionally substituted aryl, etc.

La présente invention concerne des produits prophylactiques ou de traitement contre l'arythmie qui contiennent en tant qu'ingrédient actif des inhibiteurs cPLA¿2? tels que des composés représentés par la formule (I) dans laquelle R?1¿ représente aralkyle facultativement substitué, etc. ; Z représente -S-, etc. ; X?1¿ représente (CH¿2?)¿s? -N(R?18¿)-CO- (R?18¿ représentant hydrogène, etc. ; et s représente un entier compris entre 0 et 3), etc. ; X?2¿ représente arylène facultativement substitué, etc. ; X?3¿ représente une liaison simple, etc. ; A, B et E représentent indépendamment chacun oxygène ou soufre ; D représente hydrogène, etc. ; Y?2¿ représente (CH¿2?)¿m?CO- (m représentant un entier compris entre 0 et 3), etc. ; et Y?2¿ représente aryle facultativement substitué, etc.

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