Preventives/remedies for cancer

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2496236

A compound inhibiting the activity of a protein having an amino acid sequence which is the same or substantially the same as an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:4, SEQ ID NO:7, SEQ ID NO:10, SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:25 or SEQ ID NO:27, or its salt; a compound inhibiting the expression of a gene of the above protein; an antisense polynucleotide having a base sequence, which is complementary or substantially complementary to the base sequence of a DNA encoding the above protein or its peptide fragment, or a part thereof; an antibody against the above protein or its peptide fragment, etc. are useful as preventives/remedies for cancer, apoptosis promoters for cancer cells and so on.

La présente invention concerne un composé ou un sel de celui-ci, qui inhibe l'activité d'une protéine possédant une séquence d'acide aminé qui est la même ou sensiblement la même qu'une séquence d'acide aminé représentée par SEQ ID NO: 1, SEQ ID NO: 4, SEQ ID NO: 7, SEQ ID NO: 10, SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 20, SEQ ID NO: 22, SEQ ID NO: 25 ou par SEQ ID NO: 27. La présente invention concerne aussi un composé qui inhibe l'expression d'un gène de la protéine susmentionnée, un polynucléotide antisens possédant une séquence de base qui est complémentaire ou sensiblement complémentaire de la séquence de base d'un ADN codant pour la protéine susmentionnée ou pour des fragments peptidiques de celle-ci ou pour une partie de celle-ci, un anticorps dirigé contre la protéine susmentionnée ou contre des fragments de celle-ci, etc.. Les composés de cette invention conviennent comme médicaments destinés à la prévention et au traitement du cancer, comme promoteurs d'apoptose des cellules cancéreuses etc..

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