A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) C07D 239/46 (2006.01) C07D 239/47 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2326427
Novel preventives/remedies useful in preventing and treating urinary disorder in which endothelin participates, which contain as the active ingredient compounds represented by general formula (I) or pharmacologically acceptable salts thereof and exert excellent inhibitory effects on elevated urethral resistance induced by endothelin, wherein the ring A represents phenyl substituted by hydroxy(lower alkyl); the ring B represents phenyl substituted by lower alkyl; Alk represents lower alkyl; and R represents an optionally substituted nitrogen-containing aromatic heterocyclic monocycle group.
L'invention concerne de nouveaux agents prophylactiques/thérapeutiques utilisés pour prévenir et traiter les troubles urinaires associés à l'endothéline, qui contiennent comme principe actif des composés représentés par la formule générale (I) ou leurs sels pharmacologiquement acceptables, et qui exercent d'excellents effets inhibiteurs contre une trop grande résistance urétrale induite par l'endothéline. Dans la formule, le cycle A représente un phényle substitué par un hydroxy(alkyle inférieur), l'anneau B représente un phényle substitué par un alkyle inférieur, Alk représe
Nosaka Kunio
Yamada Koichiro
Kirby Eades Gale Baker
Tanabe Seiyaku Co. Ltd.
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