Primary rat hepatocyte toxicity modeling

Details Primary rat hepatocyte toxicity modeling Primary rat hepatocyte toxicity modeling

G - Physics

01

N

G01N 33/48 (2006.01)

Patent

CA 2533922

The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes and their encoded proteins may be used as toxicity markers in drug screening and toxicity assays. The invention also includes a database of genes and/or proteins characterized by toxin-induced differential expression.

L'invention est basée sur l'élucidation des changements globaux dans l'expression génique et l'identification des marqueurs de toxicité dans des cellules ou des tissus exposés à une toxine connue. Les gènes et leurs protéines codées peuvent être utilisés comme marqueurs de toxicité dans des tests de criblage et de toxicité de médicaments. L'invention concerne également une base de données de gènes et/ou de protéines, caractérisée par une expression différentielle induite par des toxines.

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