Primitive hematopoietic stem cell preparations

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/08 (2006.01) A61K 35/14 (2006.01) C12M 1/34 (2006.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01) C12N 5/06 (2006.01) G01N 33/569 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2080255

ABSTRACT A cell preparation containing primitive hematopoietic stem cells obtained from the blood of leukemic patients. The stem cells are Philadelphia chromosome positive and produce detectable clonogenic progenitors in long term culture. A cell preparation comprising primitive hematopoietic stem cells obtained from the blood of normal individuals which produce detectable clonogenic progenitors in long term culture. Quantitative assays for the cell preparations and, methods for testing for substances which affect hematopoiesis of the hematopoietic stem cells are described.

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