C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0797 (2010.01) C12N 5/0735 (2010.01) A61K 35/30 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2424062
Described are a novel cell type in the neural lineage, and method of producing the same based on the degree of neural commitment and growth factor responsiveness in vitro and the potential to give rise to neural and non- neural progeny in vivo. The novel vell type of neural lineage and cells derived therefrom have a number of applications including applications regarding tissue engineering, transplantation and gene therap and drug discovery. Also described are suggested uses of the method and cell type including isolating genes that positively and negatively regulate the transition from an ES cell to a neural cell and generally for studying ES cell models of mammalian neural development.
L'invention concerne un nouveau type de cellule de la lignée des cellules nerveuses, et un procédé de production dudit type de cellule en fonction du degré d'implication neurale et de réaction du facteur de croissance in vitro, ainsi que de l'aptitude à engendrer une descendance neurale ou non neurale in vivo. Le nouveau type de cellule de la lignée des cellules nerveuses et les cellules issues d'elle peuvent être utilisées dans de nombreuses applications, notamment des applications se rapportant à la manipulation génétique de tissus, à la greffe et à la thérapie génique, ainsi qu'à la mise au point de médicaments. L'invention concerne en outre des utilisations possibles de la méthode et dudit type de cellules, qui consistent à isoler des gènes régulant positivement ou négativement le passage d'une cellule embryonnaire à une cellule nerveuse aux fins d'étudier des modèles de cellule embryonnaire du développement neural chez le mammifère.
Tropepe Vincent
Van Der Kooy Derek
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Tropepe Vincent
Van Der Kooy Derek
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