Prion clearance using particulate metal oxides

Details Prion clearance using particulate metal oxides Prion clearance using particulate metal oxides

C - Chemistry, Metallurgy

07

K

C07K 1/22 (2006.01) G01N 33/15 (2006.01)

Patent

CA 2538288

A method of preparing a solution containing biological material by adding a fumed metal oxide and/or particulate silicon dioxide to biological material to obtain a mixture of fumed metal oxide and/or particulate silicon dioxide and the biological material; and separating the fumed metal oxide and/or particulate silicon dioxide from the mixture to form a resulting solution, wherein any pathogenic prion proteins possibly contaminating the biological material are substantially reduced in the resulting solution.

La présente invention concerne un procédé permettant d'élaborer une solution contenant un matériau biologique. En l'occurrence, on l'additionne d'un oxyde métallique sublimé et/ou de silice particulaire. On obtient un mélange réunissant d'une part l'oxyde métallique sublimé et/ou la silice particulaire, et d'autre part le matériau biologique. Après séparation de l'oxyde métallique sublimé et/ou de la silice particulaire du mélange, il reste une solution dans laquelle la population de protéines-prions pathogènes susceptibles de contaminer le matériau biologique est fortement réduite.

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