Prion disinfection

A - Human Necessities – 01 – N

Patent

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Details

A01N 63/02 (2006.01) A01P 1/00 (2006.01) A61L 2/02 (2006.01) A61L 2/16 (2006.01)

Patent

CA 2437566

The invention relates to a methods and compositions for treating a surface, suspension or solution contaminated with a PrPScprion protein or a surrogate thereof. The methods and compositions employ a combination of one or more enzymes effective to cleave a prion protein to fragments having a non- infective molecular weight, and one or more agents selected to favour conformational unfolding of the PrPScprion protein while not denaturing the one or more enzymes.

La présente invention concerne des techniques et des compositions permettant de traiter une surface, une suspension ou une solution contaminée avec une protéine prionique PrP?Sc¿ ou un élément auxiliaire de celle-ci. Ces techniques et ces compositions utilisent une combinaison d'au moins une enzyme efficace pour cliver une protéine prionique en fragments possédant un poids moléculaire non infectieux et d'au moins un agent sélectionné de façon à favoriser le dépliage de cette protéine prionique PrP?Sc¿ sans pour autant dénaturer l'enzyme ou les enzymes précitées. .

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