Prion inactivation

Details Prion inactivation Prion inactivation

C - Chemistry, Metallurgy

07

K

C07K 1/14 (2006.01) C07K 14/775 (2006.01)

Patent

CA 2620047

Subject of the invention is a process for the inactivation of prions in a sample which comprises prion proteins or is suspected of comprising prion proteins, the process comprising a heat treatment in the presence of a lipophilic substance comprising at least 8 carbon atoms, wherein the heat treatment is performed at a temperature below 100 ~C at which the lipophilic substance is in a liquid state and under conditions wherein degradation of less than 90% of the prion proteins occurs.

L'invention porte sur un procédé d'inactivation des prions dans un échantillon qui contient des protéines de prions ou qui est présumé contenir des protéines de prions. Le procédé consiste en un traitement thermique en présence d'une substance lipophile renfermant au moins 8 atomes de carbone, le traitement thermique étant effectué à une température inférieure à 100 °C, température à laquelle la substance lipophile est à l'état liquide, et dans des conditions où se produit une dégradation du prion inférieure à 90 %.

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