Prion inhibiting peptides and derivatives thereof

Details Prion inhibiting peptides and derivatives thereof Prion inhibiting peptides and derivatives thereof

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) A61K 38/10 (2006.01) C07K 5/103 (2006.01) C07K 5/117 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2467914

Short peptides and derivatives or analogs thereof for the treatment or prevention of transmissible spongiform encephalopathies, in particular CJD are herein described. These peptides and/or their derivatives have been designed to block the conformational changes that occur in the prion protein (PrP) and which are implicated in the pathogenesis of transmissible spongiform encephalopathies as well as to dissolve the fibrillar deposits already formed

La présente invention concerne des peptides courts et des dérivés ou analogues de ceux-ci, destinés au traitement ou à la prévention d'encéphalopathies spongiformes transmissibles, en particulier de la maladie de Creutzfeldt-Jacob. Ces peptides et/ou leurs dérivés ont été élaborés pour bloquer les changements de conformations qui touchent la protéine prion (PrP) et qui sont impliqués dans la pathogenèse des encéphalopathies spongiformes transmissibles, et pour dissoudre les dépôts fibrillaires déjà formés.

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