Prion protein as a receptor for amyloid-beta oligomers

Details Prion protein as a receptor for amyloid-beta oligomers Prion protein as a receptor for amyloid-beta oligomers

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61P 25/28 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2719878

The invention provides methods of inhbiting suppression of long term potentiation, improving acute memory re-tention and spatial memory performance and treating Alzheimer's disease by administration of a PrPc antagonist or combinations thereof. Additionally, this invention provides pharmaceutical kits comprising, and methods for making and using, such combinit-tions, as well as methods of identifying molecules that could function as PrP c antagonists.

L'invention concerne des procédés d'inhibition de la suppression de la potentialisation à long terme, d'amélioration des performances de rétention de mémoire immédiate et de mémoire spatiale et de traitement de la maladie d'Alzheimer par l'administration d'un antagoniste PrPc ou de combinaisons de celui-ci. De plus, l'invention concerne des trousses pharmaceutiques comprenant de telles combinaisons et des procédés de fabrication et d'utilisation de celles-ci, ainsi que des procédés d'identification de molécules qui peuvent jouer le rôle des antagonistes PrPc.

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