Prion protein binding materials and methods of use

Details Prion protein binding materials and methods of use Prion protein binding materials and methods of use

C - Chemistry, Metallurgy

07

K

C07K 17/14 (2006.01) C07K 1/14 (2006.01) C07K 1/22 (2006.01) C07K 14/47 (2006.01) C07K 17/08 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2521438

Prion protein binding materials and methods for using the binding materials to detect or remove a prion protein from a sample, such as a biological fluid or an environmental sample. The binding materials are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), recombinant prion protein (PrPr), and proteinase resistant prion protein (PrPres). Prions from various species, including humans and hamsters, are bound by the binding materials.

Cette invention concerne des matériaux de liaison à la protéine prion ainsi que des procédés d'utilisation de ces matériaux de liaison pour la détection ou l'élimination d'une protéine prion dans un échantillon, tel qu'un fluide biologique ou un échantillon environnemental. Ces matériaux de liaison sont capables de se lier à une ou plusieurs formes de protéine prion, y compris la protéine prion cellulaire (PrPc), la protéine prion infectieuse (PrPsc), la protéine prion recombinante (PrPr) et la protéine prion résistante à la protéinase (PrPres). Des prions de diverses espèces, y compris des prions d'êtres humains et de hamsters, sont liés par ces matériaux de liaison.

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