Prion protein ligands and methods of use

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/06 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/08 (2006.01) C07K 5/06 (2006.01) C07K 5/08 (2006.01) C07K 14/47 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2507936

Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion- associated pathology in a subject.

L'invention concerne des ligands qui se lient aux protéines prions et des procédés d'utilisation de ces ligands permettant de détecter une protéine prion ou d'éliminer une protéine prion d'un échantillon, de type liquide biologique ou échantillon environnemental. Lesdits ligands peuvent se lier à une ou à plusieurs formes de protéine prion, notamment la protéine prion cellulaire (PrPc), la protéine prion infectieuse (PrPsc), et protéine prion recombinante (PrPr). Les prions provenant de diverses espèces, y compris les humains et les hamsters, sont liés par les ligands. L'invention concerne également un procédé permettant de traiter ou de retarder le développement d'une pathologie associée au prion chez un sujet.

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