Pro-apoptotic bacterial vaccines to enhance cellular immune...

A - Human Necessities – 01 – N

Patent

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A01N 63/00 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/04 (2006.01) A61K 49/00 (2006.01) C12N 1/00 (2006.01) C12N 1/12 (2006.01) C12N 1/20 (2006.01) C12N 9/00 (2006.01) C12N 9/02 (2006.01) C12N 9/14 (2006.01) C12N 15/00 (2006.01) C12N 15/01 (2006.01) C12N 15/74 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2437596

Whole-cell vaccines and methods for their use in producing protective immune responses in vertebrate hosts subsequently exposed to pathogenic bacteria. The present invention involves a method of enhancing antigen presentation by intracellular bacteria in a manner that improves vaccine efficacy. After identifying an enzyme that has an anti-apoptotic effect upon host cells infected by an intracellular microbe, the activity of the enzyme is reduced, thereby modifying the microbe so that it increases immunogenicity. Also, the present invention provides a method of incrementally modifying enzyme activity to produce incrementally attenuated mutants of the microbe from which an effective vaccine candidate can be selected.

L'invention porte sur des vaccins de cellules entières et leurs procédés d'utilisation en vue de susciter une réponse immunitaire protectrice chez des hôtes vertébrés subséquemment exposés à une bactérie pathogène. L'invention porte également sur un procédé augmentant la présentation d'antigènes par des bactéries intracellulaires afin d'améliorer l'activité d'un vaccin. Après avoir identifié une enzyme ayant un effet anti-apoptotique sur des cellules hôtes infectées par un microbe intercellulaire, on réduit l'activité de l'enzyme de façon à accroître l'immunogénicité. L'invention porte également sur un procédé de modification par incréments de l'activité d'enzymes pour produire des mutants atténués par incréments du microbe, parmi lesquels on peut sélectionner un candidat vaccin efficace.

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