Pro-drugs for cck antagonists

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 5/08 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/675 (2006.01) A61K 38/06 (2006.01) C07D 209/14 (2006.01) C07D 209/20 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07K 5/02 (2006.01) C07K 5/023 (2006.01) C07K 5/097 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2088980

Novel pro-drugs to new and unnatural dipeptoids of .alpha.-substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the dipep- toids are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment or with use of nicotine, diazepam, alcohol, cocaine, caffeine, or opioids. The pro-drugs are also useful in treat- ing and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the pro- drugs as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject pro-drug compounds in diagnostic compositions.

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