C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/18
C07J 43/00 (2006.01) C07J 21/00 (2006.01) C07J 41/00 (2006.01)
Patent
CA 1100482
ABSTRACT OF THE DISCLOSURE: The invention is concerned with new compounds of the general formula: Image (I) wherein Z represents =0, .beta.-OH or .beta.-O-R1; R1 represents Image ; R4 represents H or a straight or branched C1-C4 alkyl; R2 and R3, which may be the same or different, each represent H, a straight or branched C1-C8 alkyl or a substituted C1-C8 alkyl wherein at least one of the hydrogen atoms therein is replaced by -N(R4)2, -CON(R4)2, a halogen atom, -COOR4, -COOCH2N(R4)2 or -COOCH2-S-R4, in which R4 is defined as above; R2 and R3 can each further represent a radical of the formula Image , Image , Image or Image , wherein W represents -N(R4)2, -CON (R4)2, a halogen atom, -COOR4, -COOCH2N(R4)2 or -COOCH2-S-R4, in which R4 is defined as above, with the proviso that R2 and R3 cannot simultaneously be H; or R2 and R3 taken together represent a cyclic alkyl [-(CH2)n-] or a cyclic heteroalkyl, wherein one of the carbon atoms is replaced by ?N-R4, ?N-COR4 or ?SO, in which n is an integer of 5 to 7 and R4 is defined as above; R5 represents H, COOR4 or -CON(R4)2, in which R4 is defined as above, provided that the C4-C5 double bond in formula (I) is subject to migration to the C5-C6 position; and wherein with respect to ring (A) in formula (I), the bond between C1 and C2 can be a single or double bond; as well as new compounds of the general formula: Image (II) wherein R4, R5 and the broken lines in rings A and B are defined as above; Z represents =O or .beta.-OH; R6 represents H or Image , with the proviso that at least one of the radicals R6 is H; and R7 represents a C1-C12 straight or branched alkyl or cycloalkyl, a C2-C12 straight or branched alkenyl or cycloalkenyl, a substituted C1-C12 straight or branched alkyl or cycloalkyl or alkenyl group, Image or -(CH2)m CON(R2)2 in which m is an integer of 1 to 6 and R2 is defined as above, or a 2, 3 or 4 pyridyl, wherein at least one of the hydrogen atoms therein can be replaced by -N(R4)2, -CON(R4)2, -SOR4, a halogen atom, -COOR4, -COOCH2N(R4)2 or -COOCH2-S-R4, in which R4 is defined above, or R4 represents a radical of the formula Image , Image , Image or Image , wherein W is defined above, The compounds of the invention are useful in treating inflammation in warm-blooded animals.
288679
Bodor Nicolae S.
Sloan Kenneth B.
Interx Research Corporation
Robic Robic & Associes/associates
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